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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PRPF8
All Species:
19.7
Human Site:
S216
Identified Species:
36.11
UniProt:
Q6P2Q9
Number Species:
12
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q6P2Q9
NP_006436.3
2335
273600
S216
D
H
Q
P
L
R
D
S
R
K
Y
V
N
G
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001117328
2324
271913
S216
D
H
Q
P
L
R
D
S
R
K
Y
V
N
G
S
Dog
Lupus familis
XP_868467
2335
273550
S216
D
H
Q
P
L
R
D
S
R
K
Y
V
N
G
S
Cat
Felis silvestris
Mouse
Mus musculus
Q99PV0
2335
273598
S216
D
H
Q
P
L
R
D
S
R
K
Y
V
N
G
S
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_415805
2335
273614
N216
D
H
Q
P
L
K
D
N
R
K
Y
V
N
G
S
Frog
Xenopus laevis
NP_001080253
2335
273603
N216
D
H
L
P
L
R
D
N
R
K
Y
V
N
G
S
Zebra Danio
Brachydanio rerio
NP_957270
2342
274356
T223
E
H
Q
P
L
K
D
T
T
K
Y
V
N
G
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610735
2396
279559
D275
Y
D
H
R
P
L
V
D
T
Q
F
V
N
G
T
Honey Bee
Apis mellifera
XP_624014
2374
277137
G255
Y
E
H
K
P
L
V
G
T
K
H
V
N
G
S
Nematode Worm
Caenorhab. elegans
P34369
2329
272009
T205
Y
D
H
K
P
L
A
T
T
R
F
V
N
G
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
XP_002327417
2357
275373
K234
Y
D
H
K
P
L
V
K
T
K
L
I
N
G
P
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_178124
2382
278110
K262
Y
D
H
K
P
L
V
K
T
K
L
I
N
G
P
Baker's Yeast
Sacchar. cerevisiae
P33334
2413
279485
D289
D
S
R
P
L
E
E
D
S
K
K
V
N
G
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
98.1
99.7
N.A.
99.9
N.A.
N.A.
N.A.
99.4
98.5
97.6
N.A.
89.4
90.4
86.5
N.A.
Protein Similarity:
100
N.A.
98.5
99.8
N.A.
99.9
N.A.
N.A.
N.A.
99.6
99.4
99
N.A.
94.1
95.2
94.3
N.A.
P-Site Identity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
86.6
86.6
66.6
N.A.
20
33.3
20
N.A.
P-Site Similarity:
100
N.A.
100
100
N.A.
100
N.A.
N.A.
N.A.
100
93.3
93.3
N.A.
40
40
40
N.A.
Percent
Protein Identity:
82.4
N.A.
N.A.
81.4
60.6
N.A.
Protein Similarity:
91.3
N.A.
N.A.
90.6
75.7
N.A.
P-Site Identity:
20
N.A.
N.A.
20
46.6
N.A.
P-Site Similarity:
26.6
N.A.
N.A.
26.6
66.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
8
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
54
31
0
0
0
0
54
16
0
0
0
0
0
0
0
% D
% Glu:
8
8
0
0
0
8
8
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
16
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
8
0
0
0
0
0
100
0
% G
% His:
0
54
39
0
0
0
0
0
0
0
8
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
16
0
0
0
% I
% Lys:
0
0
0
31
0
16
0
16
0
85
8
0
0
0
0
% K
% Leu:
0
0
8
0
62
39
0
0
0
0
16
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
16
0
0
0
0
100
0
0
% N
% Pro:
0
0
0
62
39
0
0
0
0
0
0
0
0
0
24
% P
% Gln:
0
0
47
0
0
0
0
0
0
8
0
0
0
0
0
% Q
% Arg:
0
0
8
8
0
39
0
0
47
8
0
0
0
0
0
% R
% Ser:
0
8
0
0
0
0
0
31
8
0
0
0
0
0
54
% S
% Thr:
0
0
0
0
0
0
0
16
47
0
0
0
0
0
24
% T
% Val:
0
0
0
0
0
0
31
0
0
0
0
85
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
39
0
0
0
0
0
0
0
0
0
54
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _